General Information

  • ID:  hor004931
  • Uniprot ID:  P62542
  • Protein name:  Hypertrehalosaemic factor 2
  • Gene name:  NA
  • Organism:  Carausius morosus (Indian stick insect) (Dixippus morosus)
  • Family:  AKH/HRTH/RPCH family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Carausius (genus), Lonchodinae (subfamily), Lonchodidae (family), Anareolatae (infraorder), Verophasmatodea (suborder), Phasmatodea (order), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  QLTFTPNWGT
  • Length:  10
  • Propeptide:  QLTFTPNWGT
  • Signal peptide:  NA
  • Modification:  T1 Pyrrolidone carboxylic acid;T10 Threonine amide
  • Glycosylation:  T8 C-linked (Man) tryptophan
  • Mutagenesis:  NA

Activity

  • Function:  Elevate the level of trehalose in the hemolymph
  • Mechanism:  NA
  • Cross BBB:  NO
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004931_AF2.pdbhor004931_ESM.pdb

Physical Information

Mass: 132499 Formula: C54H77N13O16
Absent amino acids: ACDEHIKMRSVY Common amino acids: T
pI: 6.11 Basic residues: 0
Polar residues: 5 Hydrophobic residues: 3
Hydrophobicity: -54 Boman Index: -872
Half-Life: 0.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 39
Instability Index: -789 Extinction Coefficient cystines: 5500
Absorbance 280nm: 611.11

Literature

  • PubMed ID:  3828078
  • Title:  Primary structure of the hypertrehalosaemic factor II from the corpus cardiacum of the Indian stick insect, Carausius morosus, determined by fast atom bombardment mass spectrometry.
  • PubMed ID:  1482345
  • Title:   A tryptophan-substituted member of the AKH/RPCH family isolated from a stick insect corpus cardiacum.
  • PubMed ID:  
  • Title:   The adipokinetic hormone/red pigment-concentrating hormone family: new structures, unique post-translational modifications and a new physiological role.